World Health Organization (WHO) says Alzheimer's is the fourth leading cause of death in countries with high incomes due to increasing aging population worldwide.
Now scientists from the Salk Institute for Biological Studies, gives high hopes for a new drug can improve memory and prevent brain damage in rats. Thus a promising candidate as the first drug that can stop the progression of Alzheimer's in humans.
Salk team developed a method using living neurons grown in a laboratory container to test the effectiveness of new synthetic compounds in protecting brain cells against the pathology associated with brain aging.
Researchers begin by using a lead compound that was originally developed for the treatment of stroke and brain injury combined with the test results of chemical compounds.
But the team found these compounds can alter the chemical structure to make Alzheimer's drug to be much more powerful or well known as J147. The results of this study were published in the journal PLoS ONE.
"Alzheimer's is a complex disease, but developments in the pharmaceutical world is often focused on the amyloid pathway that failed during clinical trials," said Marguerite Prior, who led the study with Chen Qi, as quoted from Gizmag.com, Tuesday (12/20/2011).
Prior said that contrary to test these compounds in cell culture of life, then it can determine what is done by cells to various issues related to age and choose how to prevent it.
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